Children with SARS-CoV2 infection show a broad range of clinical presentations, from asymptomatic to a critical or fatal infection. In most cases, respiratory symptoms, fever, and in some cases, diarrhea, fever, and loss of smell, are typical. Some children develop severe inflammatory sequelae involving multiple organ systems, called the multisystem inflammatory syndrome in children (MIS-C). PIMS or MIS-C usually occurs 2 to 6 weeks after SARS-CoV-2 infection, and the most common symptom in all affected children is persistent fever, while other clinical features such as acute abdominal pain, muscle pain, diarrhea or vomiting, headache, and fatigue vary across affected children. Hyperemia and exanthema, a “strawberry tongue” and swollen hands and feet resembling Kawasaki´s disease have been seen in a high proportion of PIMS/MIS-C patients. Cardiovascular issues such as myocardial dysfunction, arterial hypotension, or systemic shock have also been regularly seen, while myocarditis, pericarditis, and valve and coronary artery involvement may also develop.